To study the effects of drought stress and salicylic acid and Chitosan spraying on safflower, an experiment was conducted as a split plot design as base of a randomized complete block design with three replications. The drought stress had 4 levels ascontrol and irrigation after 25, 50 and 75% of soil available water as main plots and sprayin of salicylic acid (0.424 grams per liter), chitosan solution (5 g per liter) and both of them that were considered as sub-plots. drought stress reduced the number of heads per plant, head diameter, stem diameter, number of leaves, seed weight, seed weight and increased the percentage of hollowness of the seed. Application of chitosan and salicylic acid increased the distance of the first branch from the ground, head diameter, stem diameter, number of leaves, flowers, root length and weight and yield components as number of seeds per head, seed weight per head, seed weight and unfilled seed percentage. It seems salicylic acid and chitosan spray can be sugested to develop boost crop cultivation and increase safflower yield in the province of Sistan.